Dr. Suresh C. Yadav

Principal Scientist

Discipline: Veterinary Parasitology

E-mail.ID: yadavsc@ rediffmail. Com

M. 09896427177

AREA OF RESEARCH INTERESTS:

            Presently working on development of therapeutics and diagnostics against trypanosomosis using proteomics and molecular biology techniques.

BIOGRAPHY:

Dr S C Yadav was born on January 1, 1958 and did his schooling from District Etah U. P. He has obtained his masters and doctorate degree from Agra University Agra in the years 1978 and 1985 respectivelyHe started his scientific career in 1986 as ARS Scientist (Veterinary Parasitology) from Indian Veterinary Research Institute, Izatnagar, Bareilly. During his long stay at IVRI he worked on development of vaccines and diagnostics against helminths infections . He was awarded best research paper presentation during 7th National Congress of Parasitology organized by the Indian society of Parasitology held in 1995 at Panjim, Goa. The work conducted under NATP Projects on Fasciola gigantica by him and his student bagged Dr. J. P. Dubey Young Scientist Awards 2003 and 2004 in successive years. He visited as FAO Fellow to Monash University Australia in 1999 to acquire training in Molecular Biology techniques and advance areas of teaching in Parasitology. During 2000-2002 he has distinction in foreign exchange earnings  through export of biological research material matching International standard to Monash University, Melbourne Australia.

            He was also recipient of Professor Dr. V. S. Alwar Memorial Award for best paper published in Journal of Veterinary Parasitology during 2002.  Recently, he was Awarded, best oral presentation award in the scientific session on immunology, biotechnology on trypanosomosis during  XXIII, National Congress of Veterinary Parasitology and National Symposium held in 2012 at Guwahati, Assam. He is presently working as Principal Scientist and looking after Equine Health Unit (EHU) as I/c at Hisar.

Dr. Yadav has about 70 research papers published both in International and National Journals of repute, besides several book chapters and has also edited many compendia/ laboratory manuals. Dr. Yadav has also guided seven M.Sc, M.V.Sc and one Ph.D student for their thesis work and at present one Ph D student is registered under him.

RESEARCH PROJECTS (Recently concluded):

 All the projects was funded by external agencies.             

1.    Development of biomarkers for diagnosis of Trypanosoma evansi infection in animals using proteomic approach DBT project in collaboration with Indian Institute of Science ,Banglore, (2011- 2014). Project coordinator & Co- Principal investigator.

2.    Development of targeted drug release therapeutics using nanoparticles in Equine Medicine DST project (2012- 2015) as CO-PI investigator in collaboration with GJU of Science and Technology, Hisar, Haryana.

3.    Development of nano gold based immunochromatography/immuno dot blot assay for detection of T. evansi in animals. DST project (2014-2016) in collaboration with GJU of Science and Technology, Hisar, Haryana.

PATENTS

         GRANTED

1. Polynucleotid Sequence, composition and method thereof. Utpal Tatu, Rani Pallavi, Raj kumar singh, Suresh   Chandra Yadav, (2010).   

2. Nano-drug delivery for quinapyramine sulphate against trypanosomosis. Anju Manuja, Neeraj Dilbaghi, Sandeep Kumar, Harmanmeet Kaur, Gaurav Bhanjana, Rajender   kumar, Balvinder kumar and Suresh   Chandra Yadav (2011).

3. A highly sensitive kit for detection of antibodies against Theileria equi in serum of equids. Sanjay kumar,Rajender kumar, Ashok kumar gupta, Suresh Chandra Yadav(2012).

PAPERS PUBLISHED IN RESEARCH JOURNALS

1.        Nainita Roy N., Nageshan, R.K., Pallavi, R., Chakravarthy, H, Chandran, S., Kumar, R., Gupta, A.K., Singh, R.K. , Yadav, S.C. and Tatu.U. (2010).Proteomics of Trypanosoma  evansi infection in rodents. Plos ONE: 593) e 9796

2.      Nitin Virmani, B.C. Bera, B R. Gulati, Shanmugasundaram , K, B. K. Singh, R K Vaid, S Kumar, R. Kumar, P. Malik, S. K. Khurana, J. Singh, Anju Manuja, Ramesh Dedar, A. K. Gupta, S C. Yadav, P. K. Chugh, P. S. Narwal, V. L.N. Thakur, R. Kaul, A Kanani, S. S. Rautmare and R.K. Singh (2010). Descriptive epidemiology of equine influenza in India (20082009): temporal and spatial trends. Veterinaria Italiana, 46 (4), 449.

3.   Yadav SC, Kumar R, Kumar S, Gupta AK, Tatu U (2011). Identification and characterization of cysteine proteinases of Trypanosoma evansi. Parasitol. Res. 109:559-565.

4.   Soundara Radhavan Pavithra, Raghunath Reddy, S. Venketesh, Rajender kumar Goel, Ashok kumar Gupta, Raj kumar singh, Rani Pallavi, Nainita Roy, Rishi kumar Nageshan,   Rishi kumat Nageshan, Pinak Talukdarhandra, Yadav S C, and Utpal Tatu (2010). Heat shock protein 90 as a drug target against protozoan infections: Biochemical characterization of Hsp90 from Plasmodium falciparum, Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. J.BIOl. chem 285:37964-75

5.   Yadav, S. C, Kumar Rajender, Inoue N, Yurov K,, Zablotsky,V. T, Desquesnes M, Lun Z R, Touratier L.,(2011). Detection and containment of Trypanozoon infections in equines throughout  Asia in present times.WEVA-20112-5 November, HICC, Hyderabad , India.

 6.  Yadav SC, Kumar R, Manuja A, Goyal L, Gupta AK (2012). Early detection of Trypanosoma evansi infection and monitoring of antibody levels by ELISA following treatment. Journal of parasitic diseases DOI 10.1007/s12639-012-0204-2.

7.   Kumar R., Kumar S., Khurana, S. K. and Yadav S. C. (2013). Development of antibody-ELISA and its application for sero prevalence of Trypanosoma evansiin equids of North and North-western region of India. Veterinary Parasitology(196)251-257.

8.   Kumar R., Singh J., Singh R., Kumar S.  and Yadav  S. C. (2013). Comparative efficacy of different in vitro cultivation conditions for Trypanosoma evansistrains isolated from different mammalian hosts inhabiting different geographical areas of India. Journal of Parasitic Diseases. DOI 10.1007/S12639-013-0314-5.

9.   YadavS.C. R. Kumar, Vipin Kumar, Jaideep, Ritesh Kumar, A.K. Gupta, B.C. Bera and U. Tatu (2013). Identification of Immuno-dominant antigens of Trypanosoma evansi for detection of chronic Trypanosomosis using experimental Infected equines.  Research in Veterinary sciences. 95.522-528

10. Ranjith Kumar, B.C. Saravanan, Yadav, S.C.  R.K. Goel,, R. Singh, T.A. Malik, M. Saravanan and S .Dey (2013). Neurologic trypanosomiasis in quinapyramine sulphate treated horses-Breach of blood brain barrier. Tropical Animal Health and Production. 46:371-377.

11. Sanjay Kumar, Rajender Kumar, Ashok Gupta, Suresh Yadav, Sachin Goyal, Sandip Khurana, and R. K. Singh (2013). Development of EMA-2 recombinant antigen based enzyme-linked immunosorbent assay for sero-epidemiological studies of Theileria equi infection in Indian equine population. Veterinary Parasitology198:10-17.

12. YadavS.C. R. Kumar, Vipin Kumar, Jaideep, Ritesh Kumar, A.K. Gupta, B.C. Bera and U. Tatu (2013). Identification of Immuno-dominant antigens of Trypanosoma evansi  for detection of chronic Trypanosomosis using experimental Infected equines.  Research in Veterinary sciences. 95.522-528

13  Kumar R., Kumar S., Khurana, S. K. and Yadav  S. C. (2013). Development of antibody- ELISA and its application for seroprevalence of Trypanosoma evansi in equids of     North and North-western region   of   India. Veterinary Parasitology(196)251-257.

14    Kumar R., Singh J., Singh R., Kumar S.  and Yadav  S. C. (2013). Comparative efficacy of different in vitro cultivation conditions for Trypanosoma evansi strains isolated from different mammalian hosts inhabiting different geographical areas of India. Journal of Parasitic Diseases.DOI 10.1007/s12639-013-0314-5.

15   Sanjay Kumar, Rajender Kumar, Ashok Gupta, Suresh Yadav, Sachin Goyal, Sandip Khurana, and R. K. Singh (2013). Development of EMA-2 recombinant antigen based enzyme-linked immunosorbent assay for sero-epidemiological studies of Theileria equi infection in Indian equine population Veterinary Parasitology, 8;10-17.

16    Manuja A*, Kumar P, Kumar R, Kumar B, Singha H, Sharma RK, Yadav SC. (2014). CpG-ODN class C-mediated immunostimulation and its potential against Trypanosoma evansiin equines. Int Immunopharmacol. 2014 Jul 24; 22(2):366-370.

17      Manuja A*, Kumar S., Dilbaghi N, Bhanjana G, Chopra M, Kaur H,  Kumar R, Kumar B, Singh SK, Yadav SC. (2014). Quinapyramine sulphate-loaded sodium alginate nanoparticles show enhanced trypanocidal activity. Nanomedicine. 9 (11):1625 1634. .  

18    Saini, V.K., Singh, J., Kaushik, J., Sarkhel, S.P., Kumar, S., Yadav, S.C., Gupta, A.K. and Kumar, R. (2014). Microsatellite genotyping of Trypanosoma evansi isolates from livestock of different agro-ecological zones of India. Indian Journal of Animal Sciences, 84 (7): 732-735.

19     Kumar R., Kumar S., Virmani N. and Yadav S.C. (2014). Transplacental transmission of Trypanosoma evansi from experimentally donkey mare to neonatal foal. Journal of Equine .Journal of Equine Veterinary Science, 35(4):337-341.

20      Jaideep Kumar, A. Chaudhury, B. C. Bera, Ritesh Kumar, R. Kumar, U. Tatu and S. C. Yadav (2015) Production and preliminary evaluation of Trypanosoma evansi HSP70 for antibody detection in equids. Acta Parasitologica 60(4):727-734.

21     Kumar, P., Kumar, R., Kumar, B., Singha, H., Sharma, A., Virmani, N., Yadav, S.C. and Manuja, A. (2015). CpG-ODN class C-mediated immunostimulation in rabbits experimentally infected iwht horse isolate of Trypanosoma evansi. PLOS ONE 10(6): e0127437. Doi:10.1371/journal.pone.e0127437.

22      Kumar, J., Chaudhary, A. and Yadav, S.C. (2016). Comparative evaluation of recombinant heat shock protein 70 (HSP70) fragments in detection of equine trypanosomosis. Veterinary Parasitology, 223: 77-87.

23    R K Singh, A K Tripathi, S K Singh, A P Singh and S C Yadav (2016). Seroprevalence epidemiological studies on equine trypanosomosis using Ab-ELISA in a part of semi-arid zone of northern plains of India. Indian Journal of Animal Sciences 86 (7): 743-745.

24     Gupta, A.K., Kumar, S., Sharma, P., Pal, Y., Dedar, R.K., Singh, J., Bhardwaj, A., Brahmane, M., Raut, A., Yadav, S.C. and Kumar, B. (2016). Biochemical profiles of Indian donkey population located in six different agro climatic zones. Comparative Clinical Pathology, 26: 3: 631-637.

25    Yadav, S.C., Jaideep Kumar, A K Gupta, A Jerome, Prabhat Kumar, Rajender Kumar, Kanika Tehri and Ritesh Kumar (2016). Parasitological, Biochemical and Clinical observations in ponies experimentally infected with Trypanosoma evansi. J Exp Biol Agri Sci 4:145-150

26.     Singh S, Chopra M, Dilbaghi N, Manuja BK, Kumar S, Kumar R, Rathore NS, Yadav S C, Manuja A.(2016).Synthesis and evaluation of isometamidium-alginate nanoparticles on equine mononuclear and red blood cells. Int J Biol Macromol.. 92: 788-794.

27    Anju Manuja, Balvinder Kumar, Meenu Chopra, Anshu Bajaj, Rajender Kumar, Neeraj Dilbaghi, Sandeep Kumar,  Sandeep Singh, Riyesh T, Yadav S C.(2016). Cytotoxicity and genotoxicity of a trypanocidal drug quinapyramine sulfate loaded-sodium alginate nanoparticles in mammalian cells., Int J Biol Macromol. 88:146-155

28    Kankar S.K., Kumar R., Goel S K, Gaur D.K., Sharma P., Garg R., Bera B.C. , Kumar S., Yadav S C. 2016. Quantification of Trypanosoma evansi  parasitic load in experimently infected mice  and its comparative evaluation with conventional parasitological techniques. Ind J Anim.Sci 86:1378-1384.

29     Yadav, S.C., Ritesh Kumar, Jaideep Kumar, Meetali Singh, B.C. Bera, Rajender Kumar, U. Tatu and Kanika Tehri (2017). Antigenic characterization of 52-55 kDa protein isolated from Trypanosoma evansi and its application in detection of experimental infection. Research in Veterinary Science. 114: 455-460.

30    Sarmah P C, Kakati P,  Bhattacharjee P K, Prabhat Kumar, Yadav S C* (2018). Evaluation of Formol Gel Slide Test with reference to Blood Microscopy and Enzyme Linked Immunosorbant Assay for diagnosis of surra in cattle. J Exp Biol Agri Sci  6 (2): 437-442.

31    Manuja A., Dilbaghi N., Kaur H., Saini R., Manuja B.K., Kumar R., Kumar S.,Riyesh T., Singh SK, Yadav S C. (2018). Chitosan quinapyramine sulfate nanoparticles exhibit increased trypanocidal activity in mice. Nanostructures and Nano objects.16: 193-199.

32    Anuradha Bhardwaj, Sanjay Kumar, Varij Nayan, Parvati Sharma, Yash Pal Yadav S C. (2018). Expression and characterization of recombinant single chain beta-alpha equine chorionic gonadotropin in prokaryotic host. Agriculture Research. (Accepted)

33      Ritesh Kumar,Neeraj Dilbaghi, Sandeep Kumar, A.K. Gupta, Prabhat Kumar,S. K Khurana, Yadav S C* (2018). Development and evaluation of lateral flow assay for point of care diagnosis of Trypanosomosis in equines. Journal of Equine Veterinary Sciences. (press)

34    Manuja A., Kumar B., Kumar R., Chopra M., Dilbaghi N., Kumar S.,Yadav S C. (2018). Encapsulated quinapyramine sulfate-loaded chitosan/mannitol nanoparticles: biocompatibility and targeting efficiency in rabbit model of trypanosomosis. Antimicrobial agent and chemotherapy. ( Accepted) 

Gene Accessions

1.            Yadav, S.C. B.C. Bera, Rajender Kumar, Jaideep, R. Kumar and U. Tatu (2013). Sequence analysis of full length heat shock protein 70 coding gene (hsp70) of horse isolate of Trypanosoma evansi. Sequence submitted to NCBI. Accession no.- KC351896

2.         Jaideep, Bera B.C., Chaudhary, A., Kumar R., Rochani, A,, Tatu, U and Yadav, S.C.(2014) Sequence analysis of variant surface glycoprotein ( VSG) gene of Trypanosoma evansi. Accession no. Kj13572.

Technology Developed

            The lateral flow assay (LFA) for detection of T- evansi antibodies has been developed for point of care (POC) diagnosis 2016.